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KMID : 1143420220150412695
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Public Health Weekly Report
2022 Volume.15 No. 41 p.2695 ~ p.2703
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Secondary Attack Rate and Vaccine Effectiveness Against Omicron Sub-lineage Transmissions from Index Cases to Household Contacts in Gyeongbuk
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Park Ha-Nul
Park Chung-Min
Hwang Myung-Jae
Son Tae-Jong
Choi Seong-Ju
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Abstract
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On November 30, 2021, the first case of omicron variants with fast transmission and immune avoidance characteristics
against vaccines was confirmed in the Republic of Korea. The omicron variants have been recently classified and reported in detail as BA.1.1, BA.2, BA.3, BA.4, and BA.5. For approximately 2 months from April 24 to June 27, 2022, we confirmed
the secondary attack rate and vaccine effectiveness against transmission (VET) in 82 confirmed cases of the omicron sublineage virus (BA.2.12.1, BA.4, and BA.5) and 156 household. In our study, the secondary attack rate by detailed lineage was the highest in the BA.4 variant (42.86%), followed by BA.2.12.12.1 (41.18%) and BA.5 (37.36%) variants. Regarding the BA.5 variant, the secondary attack rate was the highest among unvaccinated persons (45.45%), followed by those who had received three (35.94%) and two (33.33%) vaccine doses. When VET was confirmed, the two doses group had a VET of 30% and the three doses group had 37% compared with the unvaccinated group. But, it was not significant. The two doses group had a VET of 30% and the three doses group had 37% compared with the unvaccinated group. Our study is meaningful because it confirmed the secondary attack rate and vaccine effectiveness against Omicron sub-lineage transmissions from index cases to household contacts in Gyeongbuk.
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KEYWORD
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Omicron variant, Secondary attack rate, Vaccine effectiveness against transmission
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